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Mar 14, 2017

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100

UWHC,UWMF,

Clinical Hub,Tools & Resources,UWHC Lab Test Directory,Toxicology

Clomipramine

Clomipramine (HCCLOMI) Toxicology Lab Test

Name: Clomipramine

Test Name: Clomipramine

Health Link Test Code: HCCLOMI

LIS Test Code: CLOMI

CPT Code(s): 80335

Test Component:

Clomipramine and desmethylclomipramine

Methodology: Liquid Chromatography

Clinical Information:

Antidepressant

Days Performed: Mon-Fri, dayshift.

In-Lab Turnaround Time: 2 - 3 days.

Specimen: Blood

Collection Container: Red top

Collection Instructions:

Collect specimen for trough level prior to next dose.

Collection Volume: 4 mL

Pediatric Collection Volume: 4 mL

Stability Ambient:

5 days

Stability Refridgerated:

7 days

Stability Frozen:

1 year

Sample Analyzed: Serum

Testing Volume: 2 mL

Pediatric Testing Volume: 1.5 mL

Specimen Processing:

Centrifuge. Transfer cell-free serum to plastic vial. Refrigerate.

Specimen Transport:

Transport specimen to laboratory. Transport with coolant pack if coming from clinic location.

Unacceptable Criteria:

Specimens collected in red cap with yellow ring (SST) tubes are not acceptable.

Interpretation:

Generally effective therapeutic concentration:  
18 years and up: Clomipramine plus desmethylclomipramine 160-400 ng/mL
     
Toxic:    
18 years and up: Total tricyclic concentration of >500 ng/mL

Interpretation Type: Interpretive Guidelines

Critical Calls: yes

Additional Information:

Result of "BELOW DETECTION" indicates that the result is below method detection of 10 ng/mL. Clomipramine peak serum levels occur after 1.5 to 4 hours. Clomipramine is metabolized in the liver to the active metabolite desmethylclomipramine. The elimination half-life of clomipramine is 21 to 36 hours. The elimination half-life of the desmethyl metabolite is about 50 hours. Steady state levels occur after 7 to 14 days.

This test was developed and its performance characteristics determined by the UWHC Clinical Laboratories. This test meets the standards for clinical testing. This test should not be regarded as investigational or for research use. The US Food and Drug Administration (FDA) has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.