Mar 14, 2017




Clinical Hub,Tools & Resources,UWHC Lab Test Directory,Toxicology

Imipramine/ Desipramine

Imipramine/ Desipramine (XIDF) Toxicology Lab Test

Name: Imipramine/ Desipramine

Test Name: Imipramine/ Desipramine

Health Link Test Code: XIDF

LIS Test Code: IMI

CPT Code(s): 80335

Test Component:

Imipramine and desipramine

Methodology: Liquid Chromatography

Clinical Information:


Days Performed: Mon-Fri, dayshift.

In-Lab Turnaround Time: 2 - 3 days.

Patient Preparation:

The patient should be on the same dose for at least five days before collecting a specimen for therapeutic drug monitoring.

Specimen: Blood

Collection Container: Red top

Collection Instructions:

Collect specimen for trough level prior to next dose.

Collection Volume: 4 mL

Pediatric Collection Volume: 4 mL

Stability Ambient:

5 days

Stability Refridgerated:

7 days

Stability Frozen:

1 year

Sample Analyzed: Serum

Testing Volume: 2 mL

Pediatric Testing Volume: 1.5 mL

Specimen Processing:

Centrifuge. Transfer cell-free serum to plastic vial. Refrigerate.

Specimen Transport:

Transport specimen to laboratory. Transport with coolant pack if coming from clinic location.

Unacceptable Criteria:

Specimens collected in red cap with yellow ring (SST) tubes are not acceptable.


General effective therapeutic concentration:  
18 years and up: Imipramine plus desipramine 180-350 ng/mL
18 years and up: Total tricyclic concentration of >500 ng/mL

Interpretation Type: Interpretive Guidelines

Critical Calls: yes

Additional Information:

Result of "BELOW DETECTION" indicates that the result is below method detection limit of 10 ng/mL. The half-life of imipramine is 9-24 hours in an adult, and 6-15 hours in a child. The half-life of the metabolite, desipramine is 12-54 hours in an adult.


This test was developed and its performance characteristics determined by the UWHC Clinical Laboratories. This test meets the standards for clinical testing. This test should not be regarded as investigational or for research use. The US Food and Drug Administration (FDA) has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.