Feb 6, 2017




Clinical Hub,Tools & Resources,UWHC Lab Test Directory,Toxicology

Pain Management Profile, Urine

Pain Management Profile, Urine (HCUPAIN) Toxicology Lab Test

Name: Pain Management Profile, Urine

Test Name: Pain Management Profile, Urine

Health Link Test Code: HCUPAIN

LIS Test Code: UPAIN

CPT Code(s): 80307 or G0481

Methodology: Liquid Chromatography-Tandem Mass Spectrometry

Days Performed: Mon-Fri, dayshift.

In-Lab Turnaround Time: 3 - 5 days.

Specimen: Random urine

Collection Container: Sterile screw cap container

Collection Volume: 3 mL

Pediatric Collection Volume: 1 mL

Stability Ambient:

3 days

Stability Refridgerated:

2 weeks

Stability Frozen:

1 year

Sample Analyzed: Urine aliquot

Testing Volume: 3 mL

Pediatric Testing Volume: 1 mL



The following is a list of cut-off ranges that are used to determine the level (Low, Moderate, or High) of each of the 35 drug substances assayed in the Pain Management Profile.   

TEST: 6-MAM,amphetamine, benzoylecgonine (cocaine metabolite), MDA, MDMA, methamphetamine, codeine, hydrocodone, hydromorphone, meperidine, normeperidine, methadone, EDDP, morphine, naltrexone, oxycodone, oxymorphone, tapentadol, N-desmethyltapentadol, and tramadol
Below Low Moderate High
(ng/mL) (ng/mL) (ng/mL) (ng/mL)


301-1000 >1000
TEST: oxazepam, buprenorphine, norbuprenorphine, and naloxone
Below Low Moderate High
(ng/mL) (ng/mL) (ng/mL) (ng/mL)
<10 10-300 301-1000 >1000
TEST: alprazolam, hydroxyalprazolam, 7-aminoclonazepam, diazepam, nordiazepam, lorazepam, midazolam, temazepam
Below Low Moderate High
(ng/mL) (ng/mL) (ng/mL) (ng/mL)
<5 5-300 301-1000 >1000
TEST: fentanyl, norfentanyl   
Below Low Moderate High
(ng/mL) (ng/mL) (ng/mL) (ng/mL)
<7 7-50 51-200 >200
TEST: N-desmethyltramadol
Below Low Moderate High
(ng/mL) (ng/mL) (ng/mL) (ng/mL)
<100 100-300 301-1000 >1000



Additional Information:

The Pain Management Profile simultaneously screens and confirms the presence of 35 drug substances in human urine by LC-MS/MS and reports these drugs in semi-quantitative ranges (Low, Moderate, and High).  The assay is for the 35 drug substances listed below. No other drug substances will be detected or reported.


DRUGS OF ABUSE CLASS: 6-MAM (Heroin metabolite), amphetamine, benzoylecgonine (cocaine metabolite), MDA, MDMA, and methamphetamine.

BENZODIAZEPINES CLASS: alprazolam, hydroxyalprazolam, 7-aminoclonazepam (clonazepam metabolite), diazepam, nordiazepam, lorazepam, midazolam, oxazepam, and temazepam.

OPIOIDS CLASS: buprenorphine, norbuprenorphine, codeine, fentanyl, norfentanyl (fentanyl metabolite), hydrocodone, hydromorphone, meperidine, normeperidine (meperidine metabolite), methadone, EDDP (methadone metabolite), morphine, naloxone, naltrexone, oxycodone, oxymorphone, tapentadol, N-desmethyltapentadol (tapentadol metabolite), tramadol, N-desmethyltramadol (tramadol metabolite).



NOTE: Please call (608) 263-7029 with any questions. 


This test was developed and its performance characteristics determined by the UWHC Clinical Laboratories.  This test meets the standards for clinical testing.  This test should not be regarded as investigational or for research use.  The US Food and Drug Administration (FDA) has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.