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Mar 24, 2015

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UWHC,UWMF,

Clinical Hub,Tools & Resources,UWHC Lab Test Directory,Toxicology

Itraconazole

Itraconazole (HCITRAC) Toxicology Lab Test

Name: Itraconazole

Test Name: Itraconazole

Health Link Test Code: HCITRAC

LIS Test Code: ITRAC

CPT Code(s): 80299

Methodology: Liquid Chromatography-Tandem Mass Spectrometry

Clinical Information:

Antifungal

Days Performed: Daily, dayshift.

In-Lab Turnaround Time: 1 day.

Specimen: Blood

Collection Container: Red top

Collection Instructions:

Trough specimen collected just prior to next dose is preferred.

Collection Volume: 2 mL

Pediatric Collection Volume: 1 mL

Stability Ambient:

7 days

Stability Refridgerated:

7 days

Stability Frozen:

6 months

Sample Analyzed: Serum

Testing Volume: 1 mL

Pediatric Testing Volume: 0.3 mL

Specimen Processing:

Centrifuge. Transfer cell-free serum to plastic vial. Refrigerate.

Specimen Transport:

Transport specimen to laboratory. Transport with coolant pack if coming from clinic location.

Unacceptable Criteria:

Specimens collected in red cap with yellow ring (SST) tubes are not acceptable.

Interpretation:

Generally effective therapeutic concentration:

Itraconazole: 1.0 - 6.0 mcg/mL

Hydroxyitraconazole is an active metabolite of itraconazole but has no established therapeutic range; however, the sum of Itraconazole and Hydroxyitraconazole should be between 1.0 - 10.0 mcg/mL.

Effective Date of Reference Range: Mon, 05 Jan 2015 07:00:00 CST

Additional Information:

Result of "BELOW DETECTION" indicates that the result is below the method detection limit of 0.2 mcg/mL.

 

This test was developed and its performance characteristics determined by the UWHC Clinical Laboratories. This test meets the standards for clinical testing. This test should not be regarded as investigational or for research use. The US Food and Drug Administration (FDA) has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.