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Mar 14, 2017

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UWHC,UWMF,

Clinical Hub,Tools & Resources,UWHC Lab Test Directory,Toxicology

Primidone

Primidone (XPRIM) Toxicology Lab Test

Name: Primidone

Test Name: Primidone

Health Link Test Code: XPRIM

LIS Test Code: PRIM

CPT Code(s): 80188, 80184

Test Component:

Primidone and phenobarbital

Methodology: Gas Chromatography

Clinical Information:

Anticonvulsant

Days Performed: Mon-Fri, dayshift.

In-Lab Turnaround Time: 2 - 3 days.

Specimen: Blood

Collection Container: Red top

Collection Instructions:

Collect specimen for trough level prior to next dose.

Collection Volume: 2 mL

Pediatric Collection Volume: 1 mL

Stability Ambient:

7 days

Stability Refridgerated:

7 days

Stability Frozen:

1 year

Sample Analyzed: Serum

Testing Volume: 1 mL

Pediatric Testing Volume: 0.5 mL

Specimen Processing:

Centrifuge. Transfer cell-free serum to plastic vial. Refrigerate.

Specimen Transport:

Transport specimen to laboratory. Transport with coolant pack if coming from clinic location.

Unacceptable Criteria:

Specimens collected in red cap with yellow ring (SST) tubes are not acceptable.

Interpretation:

 Generally effective therapeutic concentration:  
 18 years and up:  
    Primidone:  5.0-12.0 mcg/mL
    Phenobarbital:  15-40 mcg/mL
   
 Toxic:  
 18 years and up:  
    Primidone:  >15 mcg/mL
    Phenobarbital:  >50 mcg/mL

      

Interpretation Type: Interpretive Guidelines

Critical Calls: yes

Additional Information:

Result of "BELOW DETECTION" indicates that the result is below the method detection limit of 0.3 mcg/mL. The half life of primidone is approximately 6-12 hours. Phenobarbital is an active metabolite of primidone.

 

This test was developed and its performance characteristics determined by the UWHC Clinical Laboratories.  This test meets the standards for clinical testing.  This test should not be regarded as investigational or for research use.  The US Food and Drug Administration (FDA) has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.