Jun 8, 2017




Clinical Hub,Tools & Resources,UWHC Lab Test Directory,Toxicology


Lidocaine (HCLIDO) Toxicology Lab Test

Name: Lidocaine

Test Name: Lidocaine

Health Link Test Code: HCLIDO

LIS Test Code: LIDO

CPT Code(s): 80176

Test Component:

Lidocaine and monoethylglycinexylidide (MEGX)

Methodology: Gas Chromatography

Clinical Information:

Antiarrhythmic, local anesthetic

Days Performed: Daily, dayshift- Pathology Resident approval is required after hours.

In-Lab Turnaround Time: 1 day.

Stat In-Lab Turnaround Time: 3 hours.

Specimen: Blood

Collection Container: Red top

Collection Instructions:

Collect specimen:

1) if lidocaine toxicity is suspected

2) whenever ventricular dysrhythmias occur despite lidocaine administration.

Collection Volume: 4 mL

Pediatric Collection Volume: 3 mL

Stability Ambient:

14 days

Stability Refridgerated:

14 days

Stability Frozen:

6 months

Sample Analyzed: Serum

Testing Volume: 2 mL

Pediatric Testing Volume: 1 mL

Specimen Processing:

Centrifuge. Transfer cell-free serum to plastic vial. Refrigerate.

Specimen Transport:

Transport specimen to laboratory. Transport with coolant pack if coming from clinic location.

Unacceptable Criteria:

Specimens collected in red cap with yellow ring (SST) tubes are not acceptable.


Generally effective therapeutic concentration:  
18 years and up:  Lidocaine 2.0-5.0 mcg/mL  
  MEGX 0.5-2.0 mcg/mL  
18 years and up:  Lidocaine >8 mcg/mL  
  MEGX >8 mcg/mL  


Interpretation Type: Interpretive Guidelines

Critical Calls: yes

Additional Information:

Result of "BELOW DETECTION" indicates that the result is below method detection limit of 0.1 mcg/mL. The half-life is approximately 1-2 hours. Lidocaine is metabolized to monoethylglycine-xylidine (MEGX).


This test was developed and its performance characteristics determined by the UWHC Clinical Laboratories.  This test meets the standards for clinical testing.  This test should not be regarded as investigational or for research use.  The US Food and Drug Administration (FDA) has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.