Name: Carbamazepine and Metabolite
Test Name: Carbamazepine and Metabolite
Health Link Test Code: HCCARB
LIS Test Code: CARB
CPT Code(s): 80156, 80157
Carbamazepine and carbamazepine-10,11-epoxide.
Methodology: Liquid Chromatography
Days Performed: Mon-Fri, dayshift.
In-Lab Turnaround Time: 1 day.
Collection Container: Red top
Collect serum sample 15-30 minutes prior to the morning dose.
Collection Volume: 3 mL
Pediatric Collection Volume: 1 mL
Sample Analyzed: Serum
Testing Volume: 1 mL
Pediatric Testing Volume: 0.3 mL
Centrifuge. Transfer cell-free serum to plastic vial. Refrigerate.
Transport specimen to laboratory. Transport with coolant pack if coming from clinic location.
Specimens collected in red cap with yellow ring (SST) tubes are not acceptable.
|Generally effective therapeutic concentration:|
|18 years and up:|
Carbamazepine-10,11-epoxide metabolite is active and should be 20-30% of parent compound. Carbamazepine-10,11-epoxide level greater than 50% of parent drug level may be toxic.
Interpretation Type: Interpretive Guidelines
Critical Calls: yes
Result of "BELOW DETECTION" indicates that the result is below the method detection limit of 0.5 mcg/mL. Carbamazepine results greater than 15.0 mcg/mL will be called. Carbamazepine-10,11-epoxide is the principle metabolite of carbamazepine and is an active metabolite whose plasma concentration may be increased in the presence of enzyme inducers, valproic acid, or felbamate.
This test was developed and its performance characteristics determined by the UWHC Clinical Laboratories. This test meets the standards for clinical testing. This test should not be regarded as investigational or for research use. The US Food and Drug Administration (FDA) has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.