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Nov 20, 2017

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Clinical Hub,Tools & Resources,UWHC Lab Test Directory,Toxicology

Acetaminophen

Acetaminophen (GM2485) Toxicology Lab Test

Name: Acetaminophen

Test Name: Acetaminophen

Health Link Test Code: GM2485

LIS Test Code: ACTM

CPT Code(s): 80307

Methodology: Enzymatic

Clinical Information:

Analgesic

Days Performed: Daily, 24 hours.

In-Lab Turnaround Time: 4 hours.

Stat In-Lab Turnaround Time: 1 hour.

Specimen: Blood

Collection Container: Red top

Also Acceptable: Green top (with lithium heparin anticoagulant)

Collection Volume: 1 mL

Pediatric Collection Volume: 0.4 mL

Stability Refridgerated:

14 days

Stability Frozen:

45 days

Sample Analyzed: Serum or plasma

Testing Volume: 0.5 mL

Pediatric Testing Volume: 0.2 mL

Specimen Processing:

Centrifuge. Transfer cell-free serum/plasma to plastic vial. Refrigerate.

Specimen Transport:

Transport specimen to the laboratory. Transport with coolant pack if coming from clinic location.

Unacceptable Criteria:

Specimens collected in red cap with yellow ring (SST) or green cap with yellow ring (PST) tubes are not acceptable.

Interpretation:

Generally effective therapeutic concentration: 10-30 ug/mL
   
Toxic: > 150 ug/mL

Critical Calls: yes

Additional Information:

If time of ingestion is unknown, samples taken 4 hours apart will give a better indication of whether toxicity exists. The concern in acetaminophen ingestion is whether:

     1. The blood concentration is increasing or decreasing

     2. The blood concentration is at a level which

         represents a threat of irreversible liver damage

     3. The potentially toxic antidote should be given.

 

This test is performed using a modification of an FDA approved method.  The performance characteristics of this test were determined by the UWHC Clinical Laboratories and meet the standards for clinical testing.