Feb 5, 2018




Clinical Hub,Tools & Resources,UWHC Lab Test Directory,Infectious Disease

Hepatitis B Core Ab, IgM

Hepatitis B Core Ab, IgM (XHBCM) Infectious Disease Lab Test

Name: Hepatitis B Core Ab, IgM

Test Name: Hepatitis B Core Ab, IgM

Health Link Test Code: XHBCM

LIS Test Code: CORM

CPT Code(s): 86705

Methodology: Chemiluminescent Immunoassay

Days Performed: Daily, 24 hours.

In-Lab Turnaround Time: 4 hours.

Stat In-Lab Turnaround Time: Not available stat.

Specimen: Blood

Collection Container: Red cap with yellow ring (SST)

Also Acceptable: Red top

Collection Volume: 3 mL

Pediatric Collection Volume: 1.5 mL

Stability Ambient:

3 days

Stability Refridgerated:

7 days

Stability Frozen:

>7 days

Sample Analyzed: Serum

Testing Volume: 1 mL

Pediatric Testing Volume: 0.5 mL

Specimen Processing:

Centrifuge. If complete barrier is not formed, transfer cell-free serum to plastic vial. Refrigerate.

Specimen Transport:

Transport specimen to the laboratory. Transport with coolant pack if coming from clinic location.


Reference Interval:  Nonreactive


Interpretive Guidelines:


Nonreactive: The presence of antibody to hepatitis B core without IgM indicates past infection with hepatitis B.  Anti-hepatitis B core antibody persists for life.


Borderline:  Repeat testing if clinically warranted. 


Reactive:  The presence of IgM antibody to hepatitis B core represents acute infection or acute resolving infection.  Anti-HBc IgM generally persists for up to 6 months if the disease resolves.  In patients who have chronic HBV infection, IgM anti-HBc can persist at low levels during viral replication.  Persons with exacerbations of chronic infection can test positive for IgM anti-HBc.      


Interpretation of Hepatitis B Test Result 

Test Limitations:

Results may be affected if patient has developed heterophillic antibodies due to exposure to animal based protein products.


The assay performance characteristics have not been established for cadaver specimens, heat inactivated specimens and body fluids other than serum.

Additional Information:

This method is approved for diagnostic testing only.  It is not approved for screening tissue donors that fall under FDA's HCT/P requirements.