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Jan 4, 2017

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100

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Clinical Hub,Tools & Resources,UWHC Lab Test Directory,Infectious Disease

Hepatitis B Core Ab, Total

Hepatitis B Core Ab, Total (HBCAB) Infectious Disease Lab Test

Name: Hepatitis B Core Ab, Total

Test Name: Hepatitis B Core Ab, Total

Health Link Test Code: HBCAB

LIS Test Code: AHBC

CPT Code(s): 86704

Methodology: Chemiluminescent Immunoassay

Clinical Information:

Detects total (IgG plus IgM) antibody to hepatitis B core antigen.

Days Performed: Daily, 24 hours.

In-Lab Turnaround Time: 4 hours.

Stat In-Lab Turnaround Time: Not available stat.

Specimen: Blood

Collection Container: Red cap with yellow ring (SST)

Also Acceptable: Red top

Collection Volume: 3 mL

Pediatric Collection Volume: 1.5 mL

Stability Ambient:

3 days

Stability Refridgerated:

7 days

Stability Frozen:

>7 days

Sample Analyzed: Serum

Testing Volume: 1 mL

Pediatric Testing Volume: 0.5 mL

Specimen Processing:

Centrifuge. If complete barrier has not formed, transfer cell-free serum to plastic vial. Refrigerate.

Specimen Transport:

Transport specimen to UWHC Hospital Laboratory. Transport with coolant pack if coming from clinic location.

Interpretation:

Nonreactive:  If HBcAb and HBsAg are positive with a negative HBsAb, a Hepatitis B Core Ab, IgM is recommended. If HBsAb and HBsAg are negative with a positive HBcAb, then Hepatitis B Viral DNA testing may aid in the interpretation of results.

 

Reactive:  Antibody to hepatitis B core antigen may be present an active infection, the window period, chronic carriage or recovery.  Please consider ordering the test hepatitis B core antibody IgM which is negative in chronic carriers. Hepatitis B Core, IgM can be ordered as an add-on test to the stored sample for a period 3 days from the collection time of this sample. After that time, a new specimen will be required. 

If HBcAb and HBsAg are positive with a negative HBsAb, a Hepatitis B Core Ab, IgM is recommended. If HBsAb and HBSAg are negative with a positive HBcAb, then Hepatitis B Viral DNA testing may aid in the interpretation of results.

 

Interpretation of Hepatitis B Test Result

Interpretation Type: Interpretive Guidelines

Test Limitations:

This method is approved for diagnostic testing only.  It is not approved for screening tissue donors that fall under FDA's HCT/P requirements.

 

The assay performance characteristics have not been established for cadaver specimens, heat inactivated specimens and body fluids other than serum.