Name: Hepatitis B Core Ab, Total
Test Name: Hepatitis B Core Ab, Total
Health Link Test Code: HBCAB
LIS Test Code: AHBC
CPT Code(s): 86704
Methodology: Chemiluminescent Immunoassay
Detects total (IgG plus IgM) antibody to hepatitis B core antigen.
Days Performed: Daily, 24 hours.
In-Lab Turnaround Time: 4 hours.
Stat In-Lab Turnaround Time: Not available stat.
Collection Container: Red cap with yellow ring (SST)
Also Acceptable: Red top
Collection Volume: 3 mL
Pediatric Collection Volume: 1.5 mL
Sample Analyzed: Serum
Testing Volume: 1 mL
Pediatric Testing Volume: 0.5 mL
Centrifuge. If complete barrier has not formed, transfer cell-free serum to plastic vial. Refrigerate.
Transport specimen to UWHC Hospital Laboratory. Transport with coolant pack if coming from clinic location.
Nonreactive: If HBcAb and HBsAg are positive with a negative HBsAb, a Hepatitis B Core Ab, IgM is recommended. If HBsAb and HBsAg are negative with a positive HBcAb, then Hepatitis B Viral DNA testing may aid in the interpretation of results.
Reactive: Antibody to hepatitis B core antigen may be present an active infection, the window period, chronic carriage or recovery. Please consider ordering the test hepatitis B core antibody IgM which is negative in chronic carriers. Hepatitis B Core, IgM can be ordered as an add-on test to the stored sample for a period 3 days from the collection time of this sample. After that time, a new specimen will be required.
If HBcAb and HBsAg are positive with a negative HBsAb, a Hepatitis B Core Ab, IgM is recommended. If HBsAb and HBSAg are negative with a positive HBcAb, then Hepatitis B Viral DNA testing may aid in the interpretation of results.
Interpretation of Hepatitis B Test Result
Interpretation Type: Interpretive Guidelines
This method is approved for diagnostic testing only. It is not approved for screening tissue donors that fall under FDA's HCT/P requirements.
The assay performance characteristics have not been established for cadaver specimens, heat inactivated specimens and body fluids other than serum.