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Mar 17, 2015

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100

UWHC,UWMF,

Clinical Hub,Tools & Resources,UWHC Lab Test Directory,Immunology

Cardiolipin Ab, IgM

Cardiolipin Ab, IgM (HCCARIGM) Immunology Lab Test

Name: Cardiolipin Ab, IgM

Test Name: Cardiolipin Ab, IgM

Health Link Test Code: HCCARIGM

LIS Test Code: CARIGM

CPT Code(s): 86147

Included In: Cardiolipin Ab, IgG/IgM

Methodology: Enzyme Immunoassay

Clinical Information:

Cardiolipin Ab testing is performed for evaluation of hypercoagulable state that may be associated with venous or arterial thromboemboli. Diseases associated with cardiolipin antibodies include SLE, drug-induced lupus, other connective tissue diseases and primary anti-phospholipid antibody syndrome.

Days Performed: Mon-Fri, dayshift - day varies.

In-Lab Turnaround Time: 1 week.

Stat In-Lab Turnaround Time: Not available stat.

Specimen: Blood

Collection Container: Red top

Also Acceptable: Red cap with yellow ring (SST)

Collection Volume: 3 mL

Pediatric Collection Volume: 1 mL

Stability Ambient:

8 hours

Stability Refridgerated:

7 days

Stability Frozen:

No limit at -20° C. Note: Avoid repeat freeze and thaw.

Sample Analyzed: Serum

Testing Volume: 1 mL

Pediatric Testing Volume: 0.3 mL

Specimen Processing:

Centrifuge. Transfer cell-free serum to plastic vial. Refrigerate.

Specimen Transport:

Transport serum sample to UWHC Hospital Laboratory. Transport with coolant pack if coming from clinic location.

Unacceptable Criteria:

Grossly hemolyzed, lipemic and turbid specimens are not acceptable.

Interpretation:

0 days and up:

IgM:  Negative (0-13 MPL)

 

Cardiolipin Ab, IgM Interpretive Guidelines:

   

0-13:  Negative
14-20:  Indeterminate
21-80:  Low-Medium Positive
>80:  Positive

 Cardiolipin Ab, IgM results are obtained with the INOVA QUANTA Lite ACA IgM (HRP) ELISA kits.

Interpretation Type: Expected Results

Test Limitations:

Rheumatoid factor, usually an IgM autoantibody, can interfere with the determination of the IgM aCL. Cardiolipin Ab, IgG and IgM values obtained with different manufacturers' assay methods may not be used interchangeably. The magnitude of the reported IgG or IgM levels cannot be correlated to an endpoint titer.