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Jan 18, 2018

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Clinical Hub,Tools & Resources,UWHC Lab Test Directory,Coagulation

Alpha 2 Antiplasmin

Alpha 2 Antiplasmin (HCA2AP) Coagulation Lab Test

Name: Alpha 2 Antiplasmin

Test Name: Alpha 2 Antiplasmin

Health Link Test Code: HCA2AP

LIS Test Code: A2AP

CPT Code(s): 85410

Methodology: Activity (Chromogenic)

Clinical Information:

Test is used for the chromogenic determination of plasmin inhibitor (alpha 2-antiplasmin) activity in human plasma. Alpha 2-antiplasmin is the major fast-acting inhibitor of the fibrinolytic enzyme plasmin and an important regulator of the fibrinolytic system.

Days Performed: Mon-Fri, dayshift - day varies. Specimens are accepted at any time. Testing required during off hours must be approved by a Coagulation physician. Call 263-5005 before collection.

In-Lab Turnaround Time: 4 - 10 days.

Stat In-Lab Turnaround Time: 1 day.

Specimen: Blood

Collection Container: Light blue top (3.2% NaCitrate)

Collection Instructions:

Do NOT draw through a line containing heparin. The venipuncture MUST be atraumatic to avoid hemolysis and contamination with tissue factors and platelets. Tube must be allowed to fill completely.

Collection Volume: Full 3.5 mL tube

Pediatric Collection Volume: Pediatric tube filled to fill mark

Stability Ambient:

4 hours on a spun tube

Stability Refridgerated:

Not acceptable

Stability Frozen:

2 weeks at -20°C; 6 month at -70°C

Sample Analyzed: Plasma

Testing Volume: 1 mL

Pediatric Testing Volume: 0.5 mL

Specimen Processing:

Centrifuge specimen to yield platelet poor plasma (platelet count should be less than 10 K/µL). Separate plasma and transfer to plastic tube or vial. Freeze plasma within 4 hours of collection at -20°C or below.

Specimen Transport:

Transport whole blood specimen at room temperature to UWHC Hospital Laboratory within 4 hours of collection. See Specimen Processing for instructions if transport criteria are not met. Transport frozen plasma aliquot on dry ice to UWHC Hospital Laboratory.

Unacceptable Criteria:

Hemolyzed specimens, clotted specimens, partially filled tubes and whole blood specimens greater than 4 hours old when received by the laboratory are not acceptable.

Interpretation:

 6 months and up:  85-150% NPP

Alpha 2 Antiplasmin in normal, full-term newborn infants may have borderline low or mildly decreased levels (>50%) which reach adult levels within 5 to 7 days postnatal. Healthy, premature infants (30-36 weeks gestation) may have mildly decreased levels which reach adult levels around 90 days postnatal.

Interpretation Type: Reference Interval