Mar 17, 2015




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Cyclic Citrullinated Peptide Ab IgG, reflex to Rheumatoid Factor

Cyclic Citrullinated Peptide Ab IgG, reflex to Rheumatoid Factor (CCPR) Chemistry Lab Test

Name: Cyclic Citrullinated Peptide Ab, IgG, reflex to Rheumatoid Factor

Test Name: Cyclic Citrullinated Peptide Ab IgG, reflex to Rheumatoid Factor

Health Link Test Code: CCPR

LIS Test Code: CCPR

CPT Code(s): 86200; 86431 if Rheumatoid Factor is reflexed

Test Component:

Cyclic Citrullinated Peptide Ab, IgG; If CCP IgG is >19 Rheumatoid Factor will be performed. 

Methodology: Enzyme Immunoassay

Clinical Information:

Studies have shown that detection of antibodies to CCP may predict the eventual development into Rheumatoid Arthritis (RA) when found in undifferentiated arthritis and is a marker of erosive disease in RA. The sensitivity of anti-CCP has been shown to be comparable to RF (50-75%) with a higher specificity (90-95%).

Days Performed: Mon-Fri, dayshift - day varies.

In-Lab Turnaround Time: 5 - 7 days.

Stat In-Lab Turnaround Time: Not available stat.

Specimen: Blood

Collection Container: Red top

Also Acceptable: Red cap with yellow ring (SST)

Collection Volume: 3 mL

Pediatric Collection Volume: 1 mL

Stability Ambient:

48 hours

Stability Refridgerated:

14 days (7 days if Rheumatoid Factor is reflexed)

Stability Frozen:

3 months at -20° C or lower. Note: Avoid repeat freeze and thaw.

Sample Analyzed: Serum

Testing Volume: 1 mL

Pediatric Testing Volume: 0.3 mL

Specimen Processing:

Centrifuge. Transfer cell free serum to plastic vial. Refrigerate.

Specimen Transport:

Transport specimen to laboratory. Transport with coolant pack if coming from clinic location.

Unacceptable Criteria:

Serum is microbially contaminated, heat-treated, grossly hemolyzed, lipemic, turbid or has added azide or other preservatives.


0 days and up: 0-19 Units


0-19 Units   


20-39 Units   

Weak Positive

40-59 Units

Moderately Positive

60 or more Units   

Strongly Positive


Interpretation Type: Reference Interval