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Clinical Hub,Patient Education,Health and Nutrition Facts For You,Respiratory

Nebulized Dornase Alfa or Pulmozyme (4932)

Nebulized Dornase Alfa or Pulmozyme (4932) - Clinical Hub, Patient Education, Health and Nutrition Facts For You, Respiratory

4932







Nebulized Dornase Alfa or Pulmozyme

Use of This Medicine
Dornase is an enzyme which breaks down protein bonds that cause your respiratory mucus to be
thick. Using Dornase on a regular basis makes it easier for you to cough up phlegm. Dornase is
clear and comes in a sterile, single dose plastic vial. Keep it in the refrigerator. Protect it from
light in its original package. If the medicine looks cloudy or discolored, throw it away.


Dosing
Each treatment is 2.5 mg one to two times a day by nebulization. Each vial contains 2.5 mg.
One vial is used for each treatment. Do not mix Dornase with any other drug or liquid.


Side Effects
Side effects to report to your doctor right away
ξ Trouble breathing
ξ Skin rash
Side effects that most often do not need medical attention
ξ Voice changes
ξ Sore throat
ξ Laryngitis
ξ Chest pain
ξ Redness of the eyes
These side effects have sometimes been noted but do go away within a few weeks after the first
treatment. However, if they continue or are bothersome, check with your doctor, nurse, or
pharmacist.


The Nebulizer Treatment
Dornase comes as a liquid and needs to be made into a mist so it can go deep into your lungs.
Certain equipment must be used to deliver Dornase properly. The air compressors that can be
used to do this are called, Pulmo-Aide®, Medimist®, Inspiration®, or Pari-Proneb®.

The nebulizers that can used are called Marquest Acorn II® disposable, Hudson T Updraft II®
disposable, Sidestream® disposable, Sidestream® reusable or PariLC Jet®.

Before beginning the treatment, wash your hands with soap and warm water, or use anti-bacterial
hand gel, to reduce the risk of infection.



A Dornase nebulizer must never be used for any other medicine. Dornase can cause
bacterial contamination to the lungs if the nebulizer is not cleaned and disinfected daily.
Also, if not cleaned properly, Dornase drug left in the nebulizer can form a thick gluey substance
and clog up the nebulizer, and reduce the amount of medicine sent to the lungs.
1. Place the contents of one vial of Dornase in the nebulizer cup and throw the empty vial away.
2. Take a slow deep breath and hold your breath for 5 seconds every few breaths. Holding your
breath helps the Dornase deposit in your lungs.
3. The treatment will last between 6-12 minutes depending on the type of nebulizer and air
compressor you use.


Cleaning and Disinfecting the Nebulizer

Daily cleaning and disinfecting of your Dornase nebulizer is extremely important to
prevent infection and keep the nebulizer working well.

How do I clean and disinfect by hand?

To clean and disinfect by hand, you can use either vinegar and water method or rubbing
alcohol method. If you have Cystic Fibrosis (CF) do not use the vinegar and water method.

Vinegar and Water Method
1. Take the nebulizer apart. Wash the pieces in warm soapy water.
2. Rinse with hot tap water.
3. Place the nebulizer pieces in a bowel and add enough vinegar and water solution to
completely cover the equipment. Make the mixture of 1 part white vinegar (5% solution
from your grocery store) to 2 parts water (1 cup vinegar to 2 cups water).
4. Soak the nebulizer for 30 minutes to 2 hours.
5. Rinse all of the parts of the nebulizer with sterile water. Do not use water from the
faucet, bottled, or distilled water; it could be contaminated. You can make water sterile
by boiling it for 5 minutes. Use this water once, and then throw it out.
6. Place the pieces on a paper towel to dry.

Rubbing Alcohol Method
1. Take the nebulizer apart. Wash the pieces in warm soapy water.
2. Rinse with hot tap water.
3. Place the nebulizer pieces in a bowl and add enough rubbing alcohol (isopropyl alcohol)
to completely cover the nebulizer pieces.
4. Soak the nebulizer pieces for 5 minutes.
5. Rinse the nebulizer pieces with sterile water. Do not use water from the faucet, bottled,
or distilled water. You can make water sterile by boiling it for 5 minutes. Use this water
once, and then throw it out.
6. Place the nebulizer pieces on a paper towel to dry.






How do I clean and disinfect by heat?

Note: Use the following heat methods only for sturdy, hard plastic nebulizer cups. Heat
cleaning may melt lighter, clear plastic nebulizers.

How do I clean and disinfect in the dishwasher
1. Take the nebulizer apart.
2. Place the pieces in a dishwasher basket on the top rack of the dishwasher.
3. After the dishwasher cycle is done, remove the pieces and shake out the extra water.
4. Air-dry the nebulizer pieces on a paper towel.

How do I clean and disinfect in the microwave?
1. Take the nebulizer apart. Wash the pieces in warm soapy water.
2. Rinse with hot water.
3. Place the nebulizer pieces in a bowl. Add enough water to completely cover the
nebulizer pieces.
4. Microwave for 3-5 minutes; shorter time in high power microwaves to keep the nebulizer
from melting.
5. Place the nebulizer pieces on a paper towel to dry.


Equipment
If you have questions or need more supplies, contact UW Home Health at (608) 203-2273.



















Your health care team may have given you this information as part of your care. If so, please use it and call if you
have any questions. If this information was not given to you as part of your care, please check with your doctor. This
is not medical advice. This is not to be used for diagnosis or treatment of any medical condition. Because each
person’s health needs are different, you should talk with your doctor or others on your health care team when using
this information. If you have an emergency, please call 911. Copyright ©5/2015. University of Wisconsin Hospitals
and Clinics Authority. All rights reserved. Produced by the Department of Nursing. HF#4932