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What is Hyaluronidase and Subcutaneous Hydration? (7455)

What is Hyaluronidase and Subcutaneous Hydration? (7455) - Clinical Hub, Patient Education, Health and Nutrition Facts For You, Pediatrics, Parenting


What is Hyaluronidase and Subcutaneous Hydration?

This is a natural substance found in the body. It also comes as a medicine
that is given under the skin. It helps separate the fatty tissue layer of the skin
so medicines can be given under the skin instead of through an intravenous
(IV) line. Side affects include a feeling of burning or coldness, and redness.

Subcutaneous Hydration (Hypodermoclysis)
This is the process of giving fluids into the fatty tissue under the skin. The
fluids can be absorbed through the many blood vessels there.

When may subcutaneous hydration be used?
It is used when:
ξ It is hard to gain IV access
ξ The patient needs some extra fluid but an IV is not needed.

What to Expect
ξ A site is chosen for the injection, such as the back, upper arm, upper
legs, or abdomen. The most common site is between the shoulder
blades of your back. There aren’t as many nerve endings here so there
is less pain.
ξ Numbing medicine will be given first.
ξ A small needle will be inserted into chosen site and secured.
ξ After the fluids start, the area may become swollen and slightly
reddened. This is normal and doesn’t last. See reverse side for
pictures. The swelling will last for an hour or more and the redness
will last for about 24 hours.
ξ There should be no pain. Call your nurse if pain occurs.

Photos courtesy of American Academy of Pediatrics -

Your health care team may have given you this information as part of your care. If so, please use it and call
if you have any questions. If this information was not given to you as part of your care, please check with
your doctor. This is not medical advice. This is not to be used for diagnosis or treatment of any medical
condition. Because each person’s health needs are different, you should talk with your doctor or others on
your health care team when using this information. If you have an emergency, please call 911.
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by the Department of Nursing. HF#7455.
A) Between the shoulder blades of the
back is the best site to give fluids this
way because:
1. There are less nerve endings and
therefore less pain.
2. There is more tissue for the fluid to be
3. It is less likely to be pulled out.
B) This is what the back will look like
after the infusion is started. This is
perfectly normal and should be expected
but it should not be painful. If the patient
has pain, please tell your nurse.
C) After about one hour, it will still be
red, but the swelling should be much less
because the fluid is being absorbed in the