Dofetilide (Tikosyn®) (oral)
About Your Medicine:
DOFETILIDE (doe-FET-i-lide) is taken to
treat an irregular heart beat called atrial
fibrillation or a-fib to make it regular. This
medicine does not cure abnormal heart
rhythms, but controls them.
If you want to learn more about your
medicine and its use, check with your
doctor, nurse or pharmacist.
Remember; keep this and all other
medicines out of the reach of children.
Never share your medicines with others.
Before Using This Medicine
Tell your doctor, nurse or pharmacist if you:
Are allergic to dofetilide or any other
drugs; either prescription or over the
Are pregnant, plan to become pregnant,
or are breastfeeding. If you become
pregnant while taking this medicine, call
your doctor right away.
Have any heart problems, including a
prolonged QT interval or “long QT
syndrome,” kidney disease, or low
potassium in the blood.
Are taking these medicines that cannot
be used with dofetilide: cimedidine
(Tagamet® ) hydrochlorothiazide with or
without triamterence (Dyazide® or
Maxzide® ), megesterol (Megace® ),
prochlorperazine (Compazine® ),
trimethoprim (Proloprim® ) trimethoprim
with sulfamethoxazole (Bactrim® or
Septra® ) or verapamil (Calon® , Covera®
or Verelan® ).
Are taking medicine for mental disorders
Are taking medicine for infections such
as erythromycin, clarithromycin
(Biaxin®), azithromycin (Zithromax® )
or moxifloxacin (Avelox®).
Are taking medicine for HIV/AIDS.
Are taking medicine for fungal
Are taking methadone.
Are taking any other medicines for
irregular heart beats or blood pressure
such as amiodarone (Cordarone®),
verapamil (Calon®, Covera®, Verelan®),
or sotalol (Betapace® ).
Always ask your doctor before you take
any new medicine, any over the counter
medicines, supplements or vitamins.
Proper Use of This Medicine
Your doctor will start you on this medicine
in the hospital to monitor your heart rate,
rhythm and blood pressure. You will be in
the hospital for at least 3 days when you
start taking this medicine.
Take dofetilide as directed by your doctor.
Do not take more or less than prescribed.
Take medicine at the same time everyday.
Do not take a double dose. Keep taking
dofetilide even if you feel well. Do not stop
taking the medicine unless told to stop by a
doctor. Missing more than two days of this
medicine may require a hospital admission
of 3 days for the medicine to be restarted.
Make sure to pick up refills for this
medicine on time. Do not run out of this
If you miss one dose of this medicine; take
missed dose as soon as you can. If it is
closer to the time you will be taking your
next dose, skip the missed dose and continue
your regular dosing schedule. If you miss
two doses, call your heart doctor
(cardiologist) about when to take the next
dose. Do not make up or catch up on doses.
Store the medicine in a tightly closed
container at room temperature away from
excess heat and moisture (not in bathroom).
Keep it out of direct light. Throw away any
expired medicine, or any that is no longer
needed. Ask your pharmacist or doctor
about the best way to dispose of medicine.
You may take this medicine with or without
food. Do not eat grapefruit or drink
grapefruit juice while taking this medicine.
Your doctor will need to check your heart
rate and rhythm at regular visits. Keep all
appointments with your doctor and for all
blood draws. Your doctor will need to
closely follow your kidney function and
blood level of potassium.
Possible Side Effects
Call your doctor right away if you notice
any of these side effects:
Allergic reaction: itching/rash or hives,
swelling in face or hands, swelling or
tingling in mouth or throat, chest
tightness or trouble breathing
Unusually fast or uneven heartbeat
Severe nausea, vomiting, or loss of
appetite or thirst
Sweating more than usual
Shortness of breath
Severe or persistent headache
Inability to move (including the face)
Trouble or pain when urinating
If you notice any of these less severe side
effects, tell your doctor if they become
severe or do not go away:
Cough, runny nose or sore throat (flu-
like or respiratory symptoms)
In case of overdose call your local poison
control center at 1-800-222-1222. If the
person that ingested the medicine has
collapsed or is not breathing, call 911.
If you notice any other side effects you think
have been caused by this medicine, tell your
doctor. Ask your doctor or pharmacist any
Your health care team may have given you this information as part of your care. If so, please use it and call if you
have any questions. If this information was not given to you as part of your care, please check with your doctor. This
is not medical advice. This is not to be used for diagnosis or treatment of any medical condition. Because each
person’s health needs are different, you should talk with your doctor or others on your health care team when using
this information. If you have an emergency, please call 911. Copyright © 9/2016 University of Wisconsin Hospitals
and Clinics Authority. All rights reserved. Produced by the Department of Nursing. HF#7021