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Desmopressin (DDAVP) for the Treatment and Prevention of Bleeding (6335)

Desmopressin (DDAVP) for the Treatment and Prevention of Bleeding (6335) - Clinical Hub, Patient Education, Health and Nutrition Facts For You, Medication Instructions


Desmopressin (DDAVP) for the Treatment and Prevention of

Desmopressin (DDAVP) is used to prevent
or treat excess bleeding in people with
bleeding disorders. DDAVP increases blood
clotting by stimulating the release of factor
VIII and von Willebrand factor from storage
sites in the body. It is commonly used by
people with mild von Willebrand disease,
platelet function disorders and mild factor
VIII deficiency (hemophilia A).

How DDAVP is Given
DDAVP can be given intravenously at a
hospital or clinic. DDAVP can also be given
in a nose spray called Stimate.® There are
generic forms of DDAVP nose spray for
treating other conditions. These generic
forms are not strong enough to treat clotting.
It is important to only use the brand
name Stimate® nose spray.

When to Use DDAVP
Your providers will teach you how and
when to use DDAVP. It is generally given
30 minutes-2 hours before a surgery or
dental procedure. It should be given as soon
as possible after a bleed or injury. DDAVP
should only be given once every 24 hours. It
should not be used for more than 3 days in a
row. DDAVP must be used with caution in
the very young, elderly, and people with
brain injury or seizure disorder and those
who have trouble with fluid imbalance.

Side Effects
More Common:
ξ Temporary facial redness
ξ Mild Headache
ξ Mild water retention
Less Common:
ξ Stuffy nose
ξ Sore Throat
ξ Mild belly cramping
ξ Low blood pressure
ξ Fast heart rate
ξ Seizures due to low blood sodium

When to Contact Your Provider
ξ If bleeding is not controlled after giving
ξ If you do not urinate within 12 hours of
taking DDAVP
ξ Any symptoms of concern, like
dizziness, fainting, confusion, vision
changes, headache not relieved with
acetaminophen (Tylenol®), fever, chills,
rash, seizure
ξ Call 911 with signs of allergic reaction
like wheezing or trouble breathing.

Recommendations for Fluid Intake
following DDAVP Administration
ξ DDAVP causes the body to retain water.
Fluid restriction is recommended for 24
hours after each dose of DDAVP. This
helps prevent rare but serious side
effects like low blood sodium level and
ξ Drink only to satisfy thirst. It is ok to
drink less than the recommended
maximum amount.
ξ Minimize plain water intake
ξ Fluid intake includes milk on cereal,
jello, popsicles, soup or broth.

Weight in
24 hour
fluid intake
Number of
8 ounce
<22 ¾ maintenance – use
22-34 24 oz 3
35-45 32 oz 4
46-67 40 oz 5
68-110 48 oz 6
111-160 56 oz 7
161-200 64 oz 8
201+ 72 oz 9
*Eight 8oz glasses is approximately 2 Liters

Instructions for use of Stimate® nasal
ξ “Prime” the Stimate® vial with 4 sprays
before the first use. Prime with 1 spray
after the first use if the vial has not been
used in 7 days.
ξ Spray the Stimate® up the nostril and
breathe in deeply.
ξ Keep a record of Stimate® use to share
with your treatment center.

ξ 1 spray (150 micrograms) if patient
weighs < 50 kilograms (110 lbs)
ξ 2 sprays (300 micrograms) if patient
weights > 50 kilograms (110 lbs)

ξ Store bottle upright at room temperature,
not to exceed 77o F.
ξ Throw the bottle away six months after
opening, after 25 sprays or once the
expiration date has been reached,
whichever comes first.

For questions or concerns contact the UW
Health Comprehensive Program for
Bleeding Disorders at (608) 890-9493 or 1-
877-737-6707. After hours contact the
pediatric or adult hematologist on call at
(608) 262-0486.

Your health care team may have given you this information as part of your care. If so, please use it and call if you
have any questions. If this information was not given to you as part of your care, please check with your doctor. This
is not medical advice. This is not to be used for diagnosis or treatment of any medical condition. Because each
person’s health needs are different, you should talk with your doctor or others on your health care team when using
this information. If you have an emergency, please call 911. Copyright 3/2017. University of Wisconsin Hospitals
and Clinics Authority. All rights reserved. Produced by the Department of Nursing HF#6335