Mitomycin/Thiotepa is a liquid medicine for the treatment of cancer. The medicine is put into
your bladder through a narrow tube called a catheter. The usual treatment is once a week for 6
weeks or as ordered by your doctor.
Before the Treatment
Do not drink fluids for 4 hours before and 2 hours after you have your treatment. This will
help you hold the medicine in your bladder.
When you arrive at the hospital, go to the main outpatient lab to have your blood drawn on
the 1st, 3rd, and 6th bladder instillation treatments. You may have your blood labs drawn up to
3 days before your treatment.
After your blood is drawn, you should go to Registration. Then, check in at the Urology
Clinic. You will be given a cup to provide a urine sample. Be sure there is a sticker with
your name on the cup.
The nurse will go over your lab and urine results. Then, the nurse will send the medicine
orders to the pharmacy where the drug will be mixed.
Expect to spend about 2 ½ hours at the hospital. The treatment itself takes about 10 minutes.
During the Treatment
A nurse will put a catheter through your urethra (urine channel) and into your bladder.
The nurse will pour the medicine into the catheter. It will flow into your bladder.
In most cases, the catheter will be removed from the bladder after the treatment is done. You
may go home after the catheter is taken out.
You should hold the medicine in your bladder for 2 hours for best results.
You may move from side to side and back to front every 15 minutes while the medicine is in
After the Treatment
Now that you have held the medicine in your bladder for 2 hours, there are things you must do.
Sit on the toilet and urinate. Empty your bladder as much as you can.
Close the toilet seat lid. Flush the toilet 2 times right after you empty your bladder.
Wash your hands and genital area very well with soap and water.
Keep sitting, flushing, and washing every time you empty your bladder during the first 6
hours after the treatment.
After you empty your bladder the first time, you should drink plenty of fluids for the rest of
the day to help flush the medicine out of your bladder.
Burning when you empty your bladder, most often the first time you urinate after the
Feeling that you need to empty your bladder often and quickly.
Decreased white blood count.
Rare Side Effects
Nausea and vomiting
Allergic reaction such as skin rash, hives, tightness in the throat
If you have any of these rare side effects, call the clinic or go to the Emergency Department if
UW Health Urology 608-263-4757
UW Health at The American Center Urology 608-440-6464
UW Health One South Park Urology 608-287-2900
After Hours, Nights, Weekends, and Holidays, the clinic number is answered by the paging
operator. Ask for the Urology Doctor on call. Leave your name and phone number with the area
code. The doctor will call you back.
Toll Free: 1-844-607-4800
Your health care team may have given you this information as part of your care. If so, please use it and call if you
have any questions. If this information was not given to you as part of your care, please check with your doctor. This
is not medical advice. This is not to be used for diagnosis or treatment of any medical condition. Because each
person’s health needs are different, you should talk with your doctor or others on your health care team when using
this information. If you have an emergency, please call 911. Copyright ©7/2015. University of Wisconsin Hospital
and Clinics Authority. All rights reserved. Produced by the Department of Nursing. HF#6939