For the Treatment of Cancer
It is a vitamin used to enhance fluorouracil.
How It Is Given
It is injected into a vein, muscle, or taken by mouth. Since this drug is used to enhance the
cancer-cell killing power of fluorouracil, doses of leucovorin are most often given before the
fluorouracil dose or sometimes before and after the dose.
Common Side Effects
Although the leucovorin itself is virtually non-toxic, the side effects of fluorouracil are often
made worse, especially diarrhea. If you are receiving leucovorin with your fluorouracil, report
any diarrhea to the clinic immediately.
Less Common Side Effects
Possible allergic reactions which may include rash, itching and /or facial flushing. Reactions are
rarely severe from this medicine.
Talk with your health care provider before taking any vitamin or herbal supplements.
Your health care team may have given you this information as part of your care. If so, please use it and call if you
have any questions. If this information was not given to you as part of your care, please check with your doctor. This
is not medical advice. This is not to be used for diagnosis or treatment of any medical condition. Because each
person’s health needs are different, you should talk with your doctor or others on your health care team when using
this information. If you have an emergency, please call 911. Copyright © 4/2017. University of Wisconsin Hospitals
and Clinics Authority. All rights reserved. Produced by the Department of Nursing. HF#5571