Clinical Hub,Patient Education,Health and Nutrition Facts For You,Cancer, BMT, Hematology

Ifosfamide (IFEX) for the Treatment of Cancer (5565)

Ifosfamide (IFEX) for the Treatment of Cancer (5565) - Clinical Hub, Patient Education, Health and Nutrition Facts For You, Cancer, BMT, Hematology


Reproduced with permission from the 1989-2007 United States Pharmacopeial Convention, Inc. Your health care
team may have given you this information as part of your care. If so, please use it and call if you have any questions.
If this information was not given to you as part of your care, please check with your doctor. This is not medical advice.
This is not to be used for diagnosis or treatment of any medical condition. Because each person’s health needs are
different, you should talk with your doctor or others on your health care team when using this information. If you have
an emergency, please call 911. Printed in 7/2017 by the University of Wisconsin Hospitals and Clinics Authority,
Department of Nursing, Madison WI. HF#5565
For the Treatment of Cancer

What it is
Ifosfamide (Ifex®) is chemotherapy given
for the treatment of cancer.

How it is given
It is infused into a vein (IV).

Common side effects
 Nausea and vomiting
 Hair loss: Hair most often grows back,
but may be a different texture or color
 Reduced blood counts (red blood cells,
white blood cells and platelets) 1-2
weeks after treatment. This can increase
your risk of infection and bleeding. It
may also cause fatigue.
 Blood in the urine (hemorrhagic
cystitis): ifosfamide can irritate the
inside of your bladder, which may lead
to bleeding. You will receive a medicine
before and after, called mesna
(Mesnex®), to help prevent this.
 Reproductive changes, which includes
irregular periods and changes in fertility

Less common side effects
 Kidney and liver function changes: these
will be monitored with your lab work
 Confusion
 Blurry vision
 Feeling sleepy or drowsy
 Change in hearing
 Mouth sores

Rare side effects
 Tingling or burning feeling, most often
in the fingers or toes (peripheral
 Low blood pressure
When to call your doctor
ξ Fever of 100.4 θ F or greater
 Nausea and vomiting not controlled by
 If you cannot take mesna tablets
 Sleepiness, dizziness, confusion
 Blood in urine, burning/pain when you
 Changes with vision or eye sight
 New or worsening numbness, tingling or
 A fast heartbeat
 Shortness of breath, a sudden weight
gain or swelling
 Hearing loss or ringing in ears

Special concerns
 You will be given a drug called Mesna
(Mesnex®) to prevent bladder irritation
 Empty bladder often and before going to
 Drink at least 3 quarts of fluid (about 12
glasses of any drink you prefer, i.e.,
water, soda, tea, coffee, milk, etc.)
during the day of the treatment and for 2
days after treatment
 You will have blood tests to check
kidney and liver function
 Speak with your doctor if you are on any
blood thinning medicine. Treatment
may require that clotting times be
checked. The dosage of blood thinning
medicines may need to be changed.