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/clinical/cckm-tools/content/beacon-protocols/supportive-care/name-122972-en.cckm

201711331

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UWHC,UWMF,

Tools,

Clinical Hub,UW Health Clinical Tool Search,UW Health Clinical Tool Search,Beacon Protocols,Supportive Care

CSC SC Romiplostim Ver 11-20-17 (HL 5868)

CSC SC Romiplostim Ver 11-20-17 (HL 5868) - Clinical Hub, UW Health Clinical Tool Search, UW Health Clinical Tool Search, Beacon Protocols, Supportive Care


CSC SC ROMIPLOSTIM VER: 11-20-17 –  Properties
Cycle 1 –  11/21/2017 through 11/27/2017 (7 days), Planned
Day 1, Cycle 1 –  Planned for 11/21/2017
Pre-Labs
CBC WITHOUT DIFFERENTIAL
Expected: S Approximate, Expires: S+365, Routine
Treatment Medications
Note to All Staff (1)
Initial dose is 1 mcg/kg subcutaneously once weekly.
Initial dose is based on actual body weight. Use the lowest dose sufficient to maintain platelet count greater than or
equal to 50K/uL as necessary to reduce the risk of bleeding. Adjust dose based on platelet count response.
Do not use to normalize platelet counts.
Dose Modifications
Dose Adjustment:
Platelets less than 50K/uL: increase weekly dose by 1 mcg/kg;
Platelets greater than 200K/uL for 2 consecutive weeks: reduce weekly dose by 1 mcg/kg;
Platelets greater than 400K/uL: withhold dose; assess platelet count weekly; when platelet count <200K/uL, resume with
the weekly dose reduced by 1 mcg/kg;
Discontinue if platelet count does not respond to a level that avoids clinically important bleeding after 4 weeks at the
maximum recommended dose of 10 mcg/kg/week.
RomiPLOStim (NPLATE) injection 1 mcg/kg (Treatment Plan)
1 mcg/kg, Subcutaneous, ONCE, 1 dose Starting when released
Maximum dose = 10 mcg/kg/week
Cycle 2 –  11/28/2017 through 12/4/2017 (7 days), Planned
Day 1, Cycle 2 –  Planned for 11/28/2017
Pre-Labs
CBC WITHOUT DIFFERENTIAL
Expected: S+7 Approximate, Expires: S+365, Routine
Treatment Medications
Note to All Staff (1)
Initial dose is 1 mcg/kg subcutaneously once weekly.
Initial dose is based on actual body weight. Use the lowest dose sufficient to maintain platelet count greater than or
equal to 50K/uL as necessary to reduce the risk of bleeding. Adjust dose based on platelet count response.
Do not use to normalize platelet counts.
Dose Modifications
Dose Adjustment:
Platelets less than 50K/uL: increase weekly dose by 1 mcg/kg;
Platelets greater than 200K/uL for 2 consecutive weeks: reduce weekly dose by 1 mcg/kg;
Platelets greater than 400K/uL: withhold dose; assess platelet count weekly; when platelet count <200K/uL, resume with
the weekly dose reduced by 1 mcg/kg;
Discontinue if platelet count does not respond to a level that avoids clinically important bleeding after 4 weeks at the
maximum recommended dose of 10 mcg/kg/week.
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Zztestonc,Fiona F [2462287]
11/21/2017 10:53:44 AM Page 1 of 2
Copyright © 2017 University of Wisconsin Hospitals and Clinics Authority
Contact: Lee Vermeulen, CCKM@uwhealth.org Last Revised: 11/2017CCKM@uwhealth.org

RomiPLOStim (NPLATE) injection
Subcutaneous, ONCE, 1 dose Starting when released
Maximum dose = 10 mcg/kg/week
Actions
Zztestonc,Fiona F [2462287]
11/21/2017 10:53:44 AM Page 2 of 2
Copyright © 2017 University of Wisconsin Hospitals and Clinics Authority
Contact: Lee Vermeulen, CCKM@uwhealth.org Last Revised:
 
11/2017CCKM@uwhealth.org